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Another study developed phasetransitional Pt (IV) NPcRGD nanoparticles with a hybrid lipidpolymer shell for ovarian cancer, which are both GSHsensitive and ultrasoundresponsive, demonstrating enhanced therapeutic efficacy and reduced side effects in in vivo models [121]

It is important to remember that the majority of the current evidence is from animal studies or preliminary clinical trials and that to date, there is little information available on the side effects

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